A major difference in side effects between Skyla and Mirena is the bleeding pattern. The IUD with copper can lead to heavy painful periods. See below for a comprehensive list of adverse effects. Whether this means no bleeding constant leakage or something in between comes down to the type of IUD you have and your own bodys reaction to. Cramps irregular menstrual periods and vaginal bleeding between periods spotting may occur especially during the first few weeks of use. Skyla may attach to or go through the uterus and cause other problems.Ĭommon Skyla side effects may include. Skyla levonorgestrel -releasing intrauterine system is an intrauterine device IUD that contains the female hormone progestin and is a contraceptive used to prevent pregnancy for up to 3 years. Headache nausea breast tenderness acne or weight. Common side effects of Skyla IUD Like other hormonal forms of birth control Skyla IUD can cause mood swings Breast tenderness or pain is common when using a Skyla IUD It has been known to cause vaginal itching or infection irregular period and changes in bleeding. Kristina Dervaitis an ObstetricianGynaecologist in Newmarket Ontario answers your IUD questions-What are the possible hormonal side effects of the. Both IUDs may trigger unscheduled spotting and bleeding. Skyla Levonorgestrel Releasing Intrauterine System Uses Dosage Side Effects Interactions Warning Pelvic pain vaginal itching or infection missed or irregular menstrual periods changes in bleeding patterns or flow especially during the first 3 to 6 months. Temporary pain bleeding or dizziness during insertion of the IUD. However because IUDs release just 20 percent of the progestin found in oral contraceptives these side effects are far less common.